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Microbiome Labs

What Is MegaSporeBiotic?

Megasporebiotic is the leading pharmaceutical-grade gut and digestive supplement on the market. It serves as an all-spore probiotic that repairs and improves gut health, and provides relief for digestive distress.

Benefits of MegaSporeBiotic

Megasporebiotic's bacillus strains starve unfriendly bacteria while feeding friendly bacteria which increases gut strength, and overall gut function.

Gut Health is central to overall health and a proper immune system. With 70% of immune cells created in the gut, it’s necessary to take the best gut supplement.

Signs You May Need MegaSporeBiotic

  • Leaky gut

  • Digestive distress

  • Weak immune system

  • Autoimmunity

  • Mold toxicity

The Research on MegaSporeBiotic

1. Most probiotic brands you’ll see on the market are dead on arrival, but MegaSpore's probiotic spores survive the anaerobic environment of your gut. 

2. If you have SIBO (Small Intestinal Bacterial Overgrowth), you also know that many probiotics can actually exacerbate symptoms by adding fuel to the fire. MegaSporeBiotic does not irritate SIBO.

3. Once MegaSporeBiotic's bacillus strains reach the colon, they are able to colonize, increase microbial diversity, work to strengthen the immune system and protect you from infection.

To learn more and see our sources, check out Bridgit's blog.

Why I Love MegaSpore: from Bridgit

“Megaspore is the darling of the functional medicine community for good reason; our clients get results from it. The unique spore-based design and strains starve unfriendly bacteria and help germinate over 80 species of friendly bacteria. Can you probiotic do that?? Start slowly and consider adding MegaPre or MegaMucosa to restore your healthy gut.”

MegaSpore Supplement Facts

Serving size: 2 capsules
Servings per container: 30

Ingredients: Proprietary Probiotic Blend (4 billion spore cells)

Bacillus Licheniformis
+ Produces proteases needed for protein digestion
+ Produces full spectrum of B vitamins

Bacillus Indicus HU36™
+ Produces RDA levels of carotenoids: lycopene, astaxanthin, beta-carotene, and lutein
+ Produces quinols and vitamins

Bacillus Subtilis HU58™
+ Produces nattokinase and vitamin K
+ Supports healthy GALT development

Bacillus Clausii
+Supports immune function
+Maintains efficacy during antibiotic treatment

Other ingredients: pharmaceutical-grade cellulose, vegetable capsule (cellulose and water)

Allergen information: This product is free from gluten, dairy, soy, artificial flavors, and MSG.

MegaSpore Suggested Use

The recommended maintenance dose is 2 capsules a day. These can be taken both at once, or one taken with lunch, and one with dinner. Once you have stabilized your gut, you could possibly take even less, like take 2 pills 3 times a week.

It's best to take with meals containing protein. Taking Megaspore with meals can help support digestion. However you can take all your daily dose at one meal, and it seems to pack more punch for healing. It's up to you.

However, when you first take it, start with 1 capsule (or 1/2 capsule if you are sensitive) and watch for reactions. Skip a day. If you have no adverse reactions, then you can move to 2/day (or 1/day next if you are proceeding slowly).

If you are recovering from antibiotic use, a leaky gut, etc, you may need to take more MegaSpore for a while, like 4-6 weeks.

If you're taking antibiotics, take at least 4 hours away from your antibiotic dose.

Die-off symptoms are possible, i.e. bloating and loose stool. This has never happened for me. But if you have an abundance of unhealthy bacteria in your gut, you could get symptoms as these bacteria 'die off.' (If you experience die off reactions, I recommend you go slower and find a good binder such as this one to help clear toxins.)

To learn more, read the patient handout here and check out the dosing guidelines here.

MegaSpore Storage

Store in a dry place, away from children. Traveling with MegaSpore is convenient, uncomplicated, and practical because it does not require refrigeration. MegaSpore survives and arrives at the site of colonization alive, so it can perform its probiotic function!

MegaSpore FAQ

  1. What if I have Candida, SIBO, or other gut infections? Will this help? Yes! Please check out my interview with Kiran Krashnin (the creator of MegaSpore) as he dishes out specific protocols for various digestive issues. Watch the video here!

  2. Can kids take MegaSpore? Yes, kids can take MegaSpore, at a dose smaller than for adults. If you have an infant or child under 25 pounds, I would just use a small sprinkle on food or on your finger (for a baby). You can also mix it into breast milk or formula. I would use it with a small child primarily to recover from antibiotic usage, or to avoid antibiotic usage.Some children, especially if born via C section, may not be developing their gut microbiome properly, and the MegaSpore could help. You might see this manifest in irregular bowel patterns or food sensitivities. We have a nice podcast on infant health with Dr. Laura Brayton here.Please discuss any probiotic therapy with your holistic or functional pediatrician. If your child is under 50 pounds, I would suggest 1/2 pill. If your child is over 50 pounds, then 1 pill. As we learned in the above questions, there could be times that a higher dose is appropriate for an older child.

  3. Can I take MegaSpore while pregnant or breastfeeding? You can absolutely take while pregnant or breastfeeding, and it's a great idea!

  4. Can I take MegaSpore while I'm on antibiotics? Yes, it's a good idea to take while on antibiotics, but you can't take them at the same time (or it won't do any good). You can take 4 hours away from your antibiotic dose.

  5. How do you ship MegaSpore in hot weather? Do you use ice packs? Since this probiotic is made up of spores, it does not get damaged by heat, so refrigeration or ice packs are not necessary. Probiotics that require refrigeration do not survive to the large intestine, but MegaSpore will survive to the large intestine and activate there.

  6. Should I take MegaSpore with food? We usually recommend taking the Megaspore with food. We use to get bacillus spores in our fruits and vegetables from the soil. Our body is most familiar with assimilating it that way.

  7. Can I take MegaSpore with antimicrobial foods (such as garlic)? Fortunately, Megaspore is very hearty and should survive just fine even if taken with a meal that contains garlic, etc. For gut supplements targeted at bad bacteria in the gut microbiome (such as oregano oil or Biocidin tincture), we recommend taking these at a different time than you take MegaSpore.


MegaSpore synergy: Did you know this product is included in our powerful Healthy Gut Starter Kit? This optimized kit includes also includes Mega IgG 2000, specially chosen to work synergistically with MegaSpore to heal your gutGrab the kit here!

Nervous about side effects? Sometimes side effects arise as part of your healing journey. Learn to avoid and diminish side effects with Bridgit's guide: Managing the Side Effects of Change. Click here to access! 

*Always ask your physician before starting this or any supplement protocol. The information on this page does not serve as medical advice. Although probiotics are generally well tolerated, these practitioner-grade products should be used with caution in elderly, immunocompromised, toxic and infected (including Lyme, Candida, GI) individuals. A strong die-off reaction is possible even at a low dose in these cases. Consult your physician prior to purchase.

"Probiotics are recognized for their long history of safe use. However, consumption in large amounts under immune-compromised state may raise several safety concerns." (source"In 2011, a report was released by the Agency for Healthcare Research and Quality (AHRQ) based on research sponsored by the National Institutes of Health and the FDA and conducted by the Southern California Evidence-based Practice Center reviewing the safety of probiotics. The authors of the report concluded that, although the existing probiotic clinical trials reveal no evidence of increased risk, 'the current literature is not well equipped to answer questions on the safety of probiotics in intervention studies with confidence.'” (source)

Notice: Items are for individual use only and not for resale. 

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